Who Is Luigi Mangione Defense Lawyer Karen Friedman Agnifilo?

• Karen Friedman Agnifilo has over 30 years of experience in criminal justice and trial litigation.
• She served as Chief Assistant District Attorney in Manhattan and led prosecutions of violent crimes.
• Currently, she is defending Luigi Mangione in a high-profile murder case.
• She is a respected legal commentator and advisor for prominent media outlets and TV shows.
• Karen is married to defense lawyer Marc Agnifilo, who represents Sean “Diddy” Combs in ongoing legal matters.

Karen Friedman Agnifilo is a highly experienced defense lawyer known for representing Luigi Mangione, who faces serious murder charges related to the shooting of UnitedHealthcare CEO Brian Thompson.

With over three decades in criminal justice, Friedman Agnifilo has a distinguished career prosecuting high-profile violent crimes and now applying her expertise in defense litigation.

Karen Friedman Agnifilo is a veteran attorney with a rich background in the Manhattan District Attorney’s Office, where she served as the Chief Assistant District Attorney and second-in-command from 2014 to 2021. Her career spans over 30 years, focusing primarily on criminal justice, litigation, and trials.

She is widely recognized for handling complex violent crime cases, including homicides with mental health components, and played a key role in establishing special prosecutor units such as Human Trafficking, Hate Crimes, and Mental Health Courts in Manhattan.

Karen Friedman Agnifilo’s Legal Career and Expertise

Friedman Agnifilo graduated from UCLA and earned her Juris Doctor from Georgetown University Law Center. Beginning her career as an Assistant District Attorney in Manhattan, she gained extensive experience in sensitive and high-stakes criminal cases.

Throughout her tenure, she was known for her prosecutorial rigor and leadership, serving as chief of the trial division and later as second-in-command of the Manhattan DA’s office. Her transition from prosecution to criminal defense brings a powerful insider’s perspective to her courtroom strategies.

Role in Defending Luigi Mangione in High-Profile Murder Case

Karen Friedman Agnifilo was hired by Luigi Mangione in late 2024 to defend him against murder charges stemming from the killing of Brian Thompson, CEO of UnitedHealthcare. Mangione faces multiple state and federal counts, including murder, connected to a fatal shooting incident outside a New York Hilton.

Friedman Agnifilo’s involvement signals a strategic defense effort given her extensive prosecutorial experience and familiarity with violent crime cases. She is representing Mangione amid intense media scrutiny and legal complexities.

Aside from her legal work, Friedman Agnifilo is an established legal analyst and commentator. She frequently appears on television and was a former CNN legal analyst. She also co-hosts a popular legal podcast with a large audience where she discusses emerging legal issues and litigation strategies.

This media presence amplifies her influence and reputation as a leading figure in criminal law.

Personal and Professional Network

Karen Friedman Agnifilo is married to Marc Agnifilo, another prominent attorney who represents rapper Sean “Diddy” Combs in a high-profile sex trafficking case.

This power-couple dynamic underscores their status in New York’s elite legal circles. Both Karen and Marc operate the law firm Agnifilo Intrater LLP, which focuses on complex criminal and sensitive legal matters.

Also Read: Was Charlie Kirk Shooter Tyler Robinson Texts To Roommate Real?

Last Updated on September 17, 2025 by 247 News Around The World