A new method for treating HIV has been developed
Scientists from the Peter Doherty Institute for Infection and Immunity in Melbourne, Australia, have taken a step towards completely eliminating HIV from the human body. The basis of the research is based on mRNA technology, known for Covid-19 vaccines. Scientists placed the mRNA in specially formulated oil capsules and delivered it to the white blood cells where HIV is hiding. This mRNA sends a signal to the cells to release the virus.
The study showed that the new generation nanoparticle design called 'LNP X' was accepted by these cells. These cells did not take up the previous generation nanoparticles and the HIV lurking there prevented the treatment.
"WE WERE LEFT BREATHLESS BY THE RESULTS WE ACHIEVE""Previously, it seemed impossible to deliver mRNA to these cells. But now, we're all breathless with the results we've achieved," said Dr. Paula Cevaal, co-author of the study.
This discovery proved that HIV can be removed from its reservoir in the body where it lies dormant. However, the next critical question remains: once this virus is released, can it be completely destroyed by the immune system or additional therapies?
The study was conducted on cells taken from HIV-positive individuals in a laboratory environment. Before it can be tried on real patients, animal experiments will first be required, followed by safety and efficacy studies. It is stated that this process could take years.
"IT CAN ALSO BE USED IN OTHER DISEASES SUCH AS CANCER"Dr. Michael Roche, senior author of the study, said this technique could be used not only for HIV but also for other diseases such as cancer.
Dr. Jonathan Stoye, a retrovirologist at the Francis Crick Institute, said the method was "the biggest advance yet" in removing HIV from its hiding place. However, Stoye warned: "Whether the entire reservoir needs to be destroyed to eradicate this virus, or whether a large portion of it will be sufficient, only time will tell."
On the other hand, Prof. Tomas Hanke from the Jenner Institute at Oxford University, although he acknowledged the importance of this discovery, said that 'reaching all HIV reservoirs in the body is currently only a dream'.
This new study is considered one of the most concrete scientific advances to date towards a permanent cure for the disease.
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